Defining Molecular Pathways for Cox2 Maturation in Mitochondrial Complex Iv

Two independent respiratory chains adapt OXPHOS performance to glycolytic switch

E Fernández-Vizarra, S López-Calcerrada, A Sierra-Magro, R Pérez-Pérez, LE Formosa, DH Hock, M Illescas, A Peñas, M Brischigliaro, S Ding, IM Fearnley, C Tzoulis, RDS Pitceathly, J Arenas, MA Martín, DA Stroud, M Zeviani, MT Ryan, C Ugalde

2022-11-01

The structural and functional organization of the mitochondrial respiratory chain (MRC) remains intensely debated. Here, we show t..

Optic atrophy–associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex I

LE Formosa, B Reljic, AJ Sharpe, DH Hock, L Muellner-Wong, DA Stroud, MT Ryan

2021-04-27

Mitochondrial disease is a debilitating condition with a diverse genetic etiology. Here, we report that TMEM126A, a protein that i..